Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma

BACKGROUND: Epithelial barrier dysfunction and increased permeability may contribute to antigen sensitization and disease progression in asthma. Claudin-18.1 is the only known lung-specific tight junction protein, but its contribution to airway barrier function or asthma is unclear. OBJECTIVES: To t...

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Publicado en:J Allergy Clin Immunol
Autores principales: Sweerus, Kelly, Lachowicz-Scroggins, Marrah, Gordon, Erin, LaFemina, Michael, Huang, Xiaozhu, Parikh, Mihir, Kanegai, Cindy, Fahy, John V., Frank, James A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073041/
https://ncbi.nlm.nih.gov/pubmed/27215490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.02.035
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