SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease

Chronic chagasic cardiomyopathy (CCM) is presented by increased oxidative/inflammatory stress and decreased mitochondrial bioenergetics. SIRT1 senses the redox changes and integrates mitochondrial metabolism and inflammation; and SIRT1 deficiency may be a major determinant in CCM. To test this, C57B...

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Опубликовано в: :PLoS Pathog
Главные авторы: Wan, Xianxiu, Wen, Jian-jun, Koo, Sue-Jie, Liang, Lisa Yi, Garg, Nisha Jain
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072651/
https://ncbi.nlm.nih.gov/pubmed/27764247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005954
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