Rheumatoid arthritis antigens homocitrulline and citrulline are generated by local myeloperoxidase and peptidyl arginine deiminases 2, 3 and 4 in rheumatoid nodule and synovial tissue

BACKGROUND: Seropositive rheumatoid arthritis (RA) is characterized by autoantibodies binding to citrullinated and homocitrullinated proteins. We wanted to study the expression patterns of these disease-associated protein forms and if the rheumatoid nodule and synovial tissue itself contain biologic...

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Détails bibliographiques
Publié dans:Arthritis Res Ther
Auteurs principaux: Turunen, Sanna, Huhtakangas, Johanna, Nousiainen, Tomi, Valkealahti, Maarit, Melkko, Jukka, Risteli, Juha, Lehenkari, Petri
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072303/
https://ncbi.nlm.nih.gov/pubmed/27765067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-1140-9
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