Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways.

We studied the alterations in skeletal muscle protein breakdown in long lasting sepsis using a rat model that reproduces a sustained and reversible catabolic state, as observed in humans. Rats were injected intravenously with live Escherichia coli; control rats were pair-fed to the intake of infecte...

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Bibliographic Details
Main Authors: Voisin, L, Breuillé, D, Combaret, L, Pouyet, C, Taillandier, D, Aurousseau, E, Obled, C, Attaix, D
Format: Artigo
Language:Inglês
Published: 1996
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC507224/
https://ncbi.nlm.nih.gov/pubmed/8601625
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