Torbafylline (HWA 448) inhibits enhanced skeletal muscle ubiquitin-proteasome-dependent proteolysis in cancer and septic rats.

The development of new pharmacological approaches for preventing muscle wasting in cancer is an important goal because cachectic patients display a reduced response to chemotherapy and radiotherapy. Xanthine derivatives such as pentoxifylline inhibit tumour necrosis factor-alpha (TNF) production, wh...

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Detalhes bibliográficos
Main Authors: Combaret, Lydie, Tilignac, Thomas, Claustre, Agnès, Voisin, Laure, Taillandier, Daniel, Obled, Christiane, Tanaka, Keiji, Attaix, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222298/
https://ncbi.nlm.nih.gov/pubmed/11772390
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