Metformin sensitizes the response of oral squamous cell carcinoma to cisplatin treatment through inhibition of NF-κB/HIF-1α signal axis

Resistance towards chemotherapy is a common complication in treatment of oral cancers, which leads to treatment failure and poor outcome. In recent years, a growing body of evidence has shown that tumour hypoxia significantly contributes to chemoresistance. Metformin, a widely used oral hypoglycaemi...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Qi, Xiaofeng, Xu, Wengguang, Xie, Junqi, Wang, Yufeng, Han, Shengwei, Wei, Zheng, Ni, Yanhong, Dong, Yingchun, Han, Wei
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5071902/
https://ncbi.nlm.nih.gov/pubmed/27762347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35788
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