From Heteroaromatic Acids and Imines to Azaspirocycles: Stereoselective Synthesis and 3D Shape Analysis

Heteroaromatic carboxylic acids have been directly coupled with imines using propylphosphonic anhydride (T3P) and NEt(iPr)(2) to form azaspirocycles via intermediate N‐acyliminium ions. Spirocyclic indolenines (3H‐indoles), azaindolenines, 2H‐pyrroles and 3H‐pyrroles were all accessed using this met...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Chambers, Sarah J., Coulthard, Graeme, Unsworth, William P., O'Brien, Peter, Taylor, Richard J. K.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5071705/
https://ncbi.nlm.nih.gov/pubmed/26918778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201600823
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