A somatically mutated human antiganglioside IgM antibody that induces experimental neuropathy in mice is encoded by the variable region heavy chain gene, V1-18.

IgM paraproteins associated with autoimmune peripheral neuropathy and anti-Pr cold agglutinins react with sialic acid epitopes present on disialylated gangliosides including GD1b, GT1b, GQ1b, and GD3. A causal relationship between the paraprotein and the neuropathy has never been proven experimental...

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Detalhes bibliográficos
Main Authors: Willison, H J, O'Hanlon, G M, Paterson, G, Veitch, J, Wilson, G, Roberts, M, Tang, T, Vincent, A
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC507167/
https://ncbi.nlm.nih.gov/pubmed/8636426
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