Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication

Enterovirus 71 (EV71) is a neurotropic enterovirus without antivirals or vaccine, and its host-pathogen interactions remain poorly understood. Here we use a human genome-wide RNAi screen to identify 256 host factors involved in EV71 replication in human rhabdomyosarcoma cells. Enrichment analyses re...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wu, Kan Xing, Phuektes, Patchara, Kumar, Pankaj, Goh, Germaine Yen Lin, Moreau, Dimitri, Chow, Vincent Tak Kwong, Bard, Frederic, Chu, Justin Jang Hann
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5071646/
https://ncbi.nlm.nih.gov/pubmed/27748395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13150
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