Fbxw7 Deletion Accelerates Kras(G12D)-Driven Pancreatic Tumorigenesis via Yap Accumulation()()()

Pancreatic cancers driven by KRAS mutations require additional mutations for tumor progression. The tumor suppressor FBXW7 is altered in pancreatic cancers, but its contribution to pancreatic tumorigenesis is unknown. To determine potential cooperation between Kras mutation and Fbxw7 inactivation in...

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Detalhes bibliográficos
Publicado no:Neoplasia
Main Authors: Zhang, Qiang, Zhang, Yaqing, Parsels, Joshua D., Lohse, Ines, Lawrence, Theodore S., Pasca di Magliano, Marina, Sun, Yi, Morgan, Meredith A.
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2016
Assuntos:
Short communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5071541/
https://ncbi.nlm.nih.gov/pubmed/27764699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2016.08.009
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