Conformational Modulation of the Farnesoid X Receptor by Prenylflavonoids: Insights from Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS), Fluorescence Titration and Molecular Docking Studies

We report on the molecular interactions of the Farnesoid X Receptor (FXR) with prenylflavonoids, an emerging class of FXR modulators. FXR is an attractive therapeutic target for mitigating metabolic syndromes (MetS) because FXR activates the inhibitory nuclear receptor, small heterodimer partner (SH...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochim Biophys Acta
Prif Awduron: Yang, Liping, Broderick, David, Campbell, Yan, Gombart, Adrian F., Stevens, Jan F., Jiang, Yuan, Hsu, Victor L., Bisson, William H., Maier, Claudia S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5071164/
https://ncbi.nlm.nih.gov/pubmed/27596062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2016.08.019
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