Conformational Modulation of the Farnesoid X Receptor by Prenylflavonoids: Insights from Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS), Fluorescence Titration and Molecular Docking Studies

We report on the molecular interactions of the Farnesoid X Receptor (FXR) with prenylflavonoids, an emerging class of FXR modulators. FXR is an attractive therapeutic target for mitigating metabolic syndromes (MetS) because FXR activates the inhibitory nuclear receptor, small heterodimer partner (SH...

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Bibliografiset tiedot
Julkaisussa:Biochim Biophys Acta
Päätekijät: Yang, Liping, Broderick, David, Campbell, Yan, Gombart, Adrian F., Stevens, Jan F., Jiang, Yuan, Hsu, Victor L., Bisson, William H., Maier, Claudia S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5071164/
https://ncbi.nlm.nih.gov/pubmed/27596062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2016.08.019
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