A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22

A unique feature of rheumatoid arthritis (RA) is the presence of anti-citrullinated protein antibodies (ACPA). Several risk factors for RA are known to increase the expression or activity of peptidyl arginine deiminases (PADs), which catalyze citrullination and, when dysregulated, can result in hype...

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Publicado en:JCI Insight
Main Authors: Chang, Hui-Hsin, Liu, Guang-Yaw, Dwivedi, Nishant, Sun, Bo, Okamoto, Yuko, Kinslow, Jennifer D., Deane, Kevin D., Demoruelle, M. Kristen, Norris, Jill M., Thompson, Paul R., Sparks, Jeffrey A., Rao, Deepak A., Karlson, Elizabeth W., Hung, Hui-Chih, Holers, V. Michael, Ho, I-Cheng
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070957/
https://ncbi.nlm.nih.gov/pubmed/27777982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90045
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