Pristane-Accelerated Autoimmune Disease in (SWR X NZB) F1 Mice Leads to Prominent Tubulointerstitial Inflammation and Human Lupus Nephritis-Like Fibrosis

Mouse models lupus nephritis (LN) have provided important insights into disease pathogenesis, although none have been able to recapitulate all features of the human disease. Using comprehensive longitudinal analyses, we characterized a novel accelerated mouse model of lupus using pristane treatment...

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Bibliographic Details
Published in:PLoS One
Main Authors: Gardet, Agnes, Chou, Wei C., Reynolds, Taylor L., Velez, Diana B., Fu, Kai, Czerkowicz, Julia M., Bajko, Jeffrey, Ranger, Ann M., Allaire, Normand, Kerns, Hannah M., Ryan, Sarah, Legault, Holly M., Dunstan, Robert W., Lafyatis, Robert, Lukashev, Matvey, Viney, Joanne L., Browning, Jeffrey L., Rabah, Dania
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070861/
https://ncbi.nlm.nih.gov/pubmed/27760209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164423
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