Anti-BDCA2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc-dependent and Fc-independent mechanisms

Type I interferons (IFN-I) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). In SLE, immune complexes bind to the CD32a (FcγRIIa) receptor on the surface of plasmacytoid dendritic cells (pDCs) and stimulate the secretion of IFN-I from pDCs. BDCA2 is a pDC-specific receptor th...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:EMBO Mol Med
मुख्य लेखकों: Pellerin, Alex, Otero, Karel, Czerkowicz, Julie M, Kerns, Hannah M, Shapiro, Renée I, Ranger, Ann M, Otipoby, Kevin L, Taylor, Frederick R, Cameron, Thomas O, Viney, Joanne L, Rabah, Dania
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: BlackWell Publishing Ltd 2015
विषय:
Research Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403047/
https://ncbi.nlm.nih.gov/pubmed/25762615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404719
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