Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats.

While it is known that nitric oxide (NO) is an important modulator of tone in the hypertensive pulmonary circulation, the roles of cyclic 3'-5'-guanosine monophosphate (cGMP) and cGMP-phosphodiesterase (PDE) are uncertain. We found that isolated lung perfusate levels of cGMP were over ninefold eleva...

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Библиографические подробности

Опубликовано в::	J Clin Invest
Главные авторы:	Cohen, A H, Hanson, K, Morris, K, Fouty, B, McMurty, I F, Clarke, W, Rodman, D M
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Clinical Investigation 1996
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507076/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8550830/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118386
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