Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats.

While it is known that nitric oxide (NO) is an important modulator of tone in the hypertensive pulmonary circulation, the roles of cyclic 3'-5'-guanosine monophosphate (cGMP) and cGMP-phosphodiesterase (PDE) are uncertain. We found that isolated lung perfusate levels of cGMP were over ninefold eleva...

Descripción completa

Detalles Bibliográficos

Publicado en:	J Clin Invest
Autores principales:	Cohen, A H, Hanson, K, Morris, K, Fouty, B, McMurty, I F, Clarke, W, Rodman, D M
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 1996
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507076/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8550830/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118386
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!