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High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes

BACKGROUND: African trypanosomes cause lethal diseases in humans and animals and escape host immune attack by switching the expression of Variant Surface Glycoprotein (VSG) genes. The expressed VSGs are located at the ends of telomeric, polycistronic transcription units known as VSG expression sites...

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Veröffentlicht in:BMC Genomics
Hauptverfasser: Hutchinson, Sebastian, Glover, Lucy, Horn, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070307/
https://ncbi.nlm.nih.gov/pubmed/27756224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-3154-8
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