In vitro and in vivo effects of leukotriene B4 antagonism in a primate model of asthma.

To test the hypothesis that leukotriene (LT) B4 antagonists may be clinically useful in the treatment of asthma, CP-105,696 was evaluated in vitro, using chemotaxis and flow cytometry assays, and in vivo, using a primate asthma model. CP-105,696 inhibited LTB4-mediated monkey neutrophil chemotaxis (...

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Autors principals: Turner, C R, Breslow, R, Conklyn, M J, Andresen, C J, Patterson, D K, Lopez-Anaya, A, Owens, B, Lee, P, Watson, J W, Showell, H J
Format: Artigo
Idioma:Inglês
Publicat: 1996
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC507028/
https://ncbi.nlm.nih.gov/pubmed/8567958
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