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Caspase-1 Activation Protects Lung Endothelial Barrier Function during Infection-Induced Stress
Dysregulated activation of the inflammasome–caspase-1–IL-1β axis elicits damaging hyperinflammation during critical illnesses, such as pneumonia and sepsis. However, in critical illness models of Salmonella infection, burn, or shock, caspase-1 inhibition worsens outcomes. These paradoxical effects s...
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| Publicado no: | Am J Respir Cell Mol Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Thoracic Society
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5070108/ https://ncbi.nlm.nih.gov/pubmed/27119735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0386OC |
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