SMG-1 Is a Phosphatidylinositol Kinase-Related Protein Kinase Required for Nonsense-Mediated mRNA Decay in Caenorhabditis elegans

Eukaryotic messenger RNAs containing premature stop codons are selectively and rapidly degraded, a phenomenon termed nonsense-mediated mRNA decay (NMD). Previous studies with both Caenohabditis elegans and mammalian cells indicate that SMG-2/human UPF1, a central regulator of NMD, is phosphorylated...

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Bibliographische Detailangaben
Hauptverfasser: Grimson, Andrew, O'Connor, Sean, Newman, Carrie Loushin, Anderson, Philip
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC506987/
https://ncbi.nlm.nih.gov/pubmed/15314158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.17.7483-7490.2004
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