A Partial E3 Deletion in Replication-Defective Adenoviral Vectors Allows for Stable Expression of Potentially Toxic Transgene Products

Adenovirus (Ad) is used extensively for construction of viral vectors, most commonly with deletion in its E1 and/or E3 genomic regions. Previously, our attempts to insert envelope proteins (Env) of HIV-1 into such vectors based on chimpanzee-derived Ad (AdC) viruses were thwarted. Here, we describe...

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Vydáno v:Hum Gene Ther Methods
Hlavní autoři: Haut, Larissa H., Gill, Amanda L., Kurupati, Raj K., Bian, Ang, Li, Yan, Giles-Davis, Wynetta, Xiang, Zhiquan, Zhou, Xiang Yang, Ertl, Hildegund C. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2016
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069709/
https://ncbi.nlm.nih.gov/pubmed/27604324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2016.044
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