Characterization of a Thermostable 8-Oxoguanine DNA Glycosylase Specific for GO/N Mismatches from the Thermoacidophilic Archaeon Thermoplasma volcanium

The oxidation of guanine (G) to 7,8-dihydro-8-oxoguanine (GO) forms one of the major DNA lesions generated by reactive oxygen species (ROS). The GO can be corrected by GO DNA glycosylases (Ogg), enzymes involved in base excision repair (BER). Unrepaired GO induces mismatched base pairing with adenin...

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Pubblicato in:Archaea
Autori principali: Fujii, Miki, Hata, Chieri, Ukita, Munetada, Fukushima, Chie, Matsuura, Chihiro, Kawashima-Ohya, Yoshie, Tomobe, Koji, Kawashima, Tsuyoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069365/
https://ncbi.nlm.nih.gov/pubmed/27799846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/8734894
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