Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GluN2A-Containing NMDA Receptors

NMDA receptors are Ca(2+)-permeable ion channels. The activation of NMDA receptors requires agonist glutamate and co-agonist glycine. Recent evidence indicates that NMDA receptor also has metabotropic function. Here we report that in cultured mouse hippocampal neurons, glycine increases AMPA recepto...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Li, Li-Jun, Hu, Rong, Lujan, Brendan, Chen, Juan, Zhang, Jian-Jian, Nakano, Yasuko, Cui, Tian-Yuan, Liao, Ming-Xia, Chen, Jin-Cao, Man, Heng-Ye, Feng, Hua, Wan, Qi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069295/
https://ncbi.nlm.nih.gov/pubmed/27807405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2016.00102
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