Glycine triggers a non-ionotropic activity of GluN2A-containing NMDA receptors to confer neuroprotection

Ionotropic activation of NMDA receptors (NMDARs) requires agonist glutamate and co-agonist glycine. Here we show that glycine enhances the activation of cell survival-promoting kinase Akt in cultured cortical neurons in which both the channel activity of NMDARs and the glycine receptors are pre-inhi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Principais autores: Hu, Rong, Chen, Juan, Lujan, Brendan, Lei, Ruixue, Zhang, Mi, Wang, Zefen, Liao, Mingxia, Li, Zhiqiang, Wan, Yu, Liu, Fang, Feng, Hua, Wan, Qi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5046082/
https://ncbi.nlm.nih.gov/pubmed/27694970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34459
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