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Selective Gas-Phase Ion/Ion Reactions: Enabling Disulfide Mapping via Oxidation and Cleavage of Disulfide Bonds in Intermolecularly-Linked Polypeptide Ions

The selective gas-phase oxidation of disulfide bonds to their thiosulfinate form using ion/ion reactions and subsequent cleavage is demonstrated here. Oxidizing reagent anions are observed to attach to all polypeptides, regardless of amino acid composition. Direct proton transfer yielding a charge-r...

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Bibliografische gegevens
Gepubliceerd in:Anal Chem
Hoofdauteurs: Pilo, Alice L., McLuckey, Scott A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068824/
https://ncbi.nlm.nih.gov/pubmed/27531151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.6b01043
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