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Cisplatin DNA damage and repair maps of the human genome at single-nucleotide resolution
Cisplatin is a major anticancer drug that kills cancer cells by damaging their DNA. Cancer cells cope with the drug by removal of the damages with nucleotide excision repair. We have developed methods to measure cisplatin adduct formation and its repair at single-nucleotide resolution. “Damage-seq”...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5068337/ https://ncbi.nlm.nih.gov/pubmed/27688757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614430113 |
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