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Quantitative modeling of DNA–protein interactions: effects of amino acid substitutions on binding specificity of the Mnt repressor

Understanding DNA–protein recognition quantitatively is essential to developing computational algorithms for accurate transcriptional binding site prediction. Using a quantitative, multiple fluorescence, relative affinity (QuMFRA) assay, we determine the binding specificity of 11 different position...

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Bibliographic Details
Main Authors: Man, Tsz-Kwong, Yang, Joshua SungWoo, Stormo, Gary D.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2004
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC506813/
https://ncbi.nlm.nih.gov/pubmed/15289576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh729
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