Quantitative modeling of DNA–protein interactions: effects of amino acid substitutions on binding specificity of the Mnt repressor

Understanding DNA–protein recognition quantitatively is essential to developing computational algorithms for accurate transcriptional binding site prediction. Using a quantitative, multiple fluorescence, relative affinity (QuMFRA) assay, we determine the binding specificity of 11 different position...

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Bibliografiske detaljer

Udgivet i:	Nucleic Acids Res
Principais autores:	Man, Tsz-Kwong, Yang, Joshua SungWoo, Stormo, Gary D.
Format:	Artigo
Sprog:	Inglês
Udgivet:	Oxford University Press 2004
Fag:	Articles
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC506813/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15289576/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh729
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