Anti-PD-1 increases the clonality and activity of tumor infiltrating antigen specific T cells induced by a potent immune therapy consisting of vaccine and metronomic cyclophosphamide

BACKGROUND: Future cancer immunotherapies will combine multiple treatments to generate functional immune responses to cancer antigens through synergistic, multi-modal mechanisms. In this study we explored the combination of three distinct immunotherapies: a class I restricted peptide-based cancer va...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Weir, Genevieve M., Hrytsenko, Olga, Quinton, Tara, Berinstein, Neil L., Stanford, Marianne M., Mansour, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067905/
https://ncbi.nlm.nih.gov/pubmed/27777777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-016-0169-2
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