Wnt Signaling Inhibition Deprives Small Intestinal Stem Cells of Clonogenic Capacity

The Wnt pathway plays a crucial role in self‐renewal and differentiation of cells in the adult gut. In the present study, we revealed the functional consequences of inhibition of canonical Wnt signaling in the intestinal epithelium. The study was based on generation of a novel transgenic mouse strai...

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Veröffentlicht in:Genesis
Hauptverfasser: Janeckova, Lucie, Fafilek, Bohumil, Krausova, Michaela, Horazna, Monika, Vojtechova, Martina, Alberich‐Jorda, Meritxell, Sloncova, Eva, Galuskova, Katerina, Sedlacek, Radislav, Anderova, Miroslava, Korinek, Vladimir
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067622/
https://ncbi.nlm.nih.gov/pubmed/26864984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvg.22922
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