Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2

Elevated levels of circulating asymmetric and symmetric dimethylarginines (ADMA and SDMA) predict and potentially contribute to end organ damage in cardiovascular diseases. Alanine-glyoxylate aminotransferase 2 (AGXT2) regulates systemic levels of ADMA and SDMA, and also of beta-aminoisobutyric acid...

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Publicado no:Sci Rep
Main Authors: Burdin, Dmitry V., Kolobov, Alexey A., Brocker, Chad, Soshnev, Alexey A., Samusik, Nikolay, Demyanov, Anton V., Brilloff, Silke, Jarzebska, Natalia, Martens-Lobenhoffer, Jens, Mieth, Maren, Maas, Renke, Bornstein, Stefan R., Bode-Böger, Stefanie M., Gonzalez, Frank, Weiss, Norbert, Rodionov, Roman N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067591/
https://ncbi.nlm.nih.gov/pubmed/27752141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35503
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