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Phase 1 Study of Safety, Tolerability, and Pharmacokinetics of PTC299, an Inhibitor of Stress‐Regulated Protein Translation

PTC299 is a novel small molecule that specifically blocks the production of protein from selected mRNAs that under certain conditions use noncanonical ribosomal translational pathways. Hypoxia, oncogenic transformation, and viral infections limit normal translation and turn on these noncanonical tra...

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書目詳細資料
發表在:Clin Pharmacol Drug Dev
Main Authors: Weetall, Marla, Davis, Thomas, Elfring, Gary, Northcutt, Valerie, Cao, Liangxian, Moon, Young‐Choon, Riebling, Peter, Dali, Mandar, Hirawat, Samit, Babiak, John, Colacino, Joseph, Almstead, Neil, Spiegel, Robert, Peltz, Stuart W.
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2016
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066743/
https://ncbi.nlm.nih.gov/pubmed/27310330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.240
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