Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis

Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens and estrogens. According to the free hormone hypothesis, SHBG modulates the bioactivity of sex steroids by limiting their diffusion into target tissues. Still, the in vivo physiological role of circulating SHBG re...

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Publicado en:Sci Rep
Main Authors: Laurent, Michaël R., Hammond, Geoffrey L., Blokland, Marco, Jardí, Ferran, Antonio, Leen, Dubois, Vanessa, Khalil, Rougin, Sterk, Saskia S., Gielen, Evelien, Decallonne, Brigitte, Carmeliet, Geert, Kaufman, Jean-Marc, Fiers, Tom, Huhtaniemi, Ilpo T., Vanderschueren, Dirk, Claessens, Frank
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066276/
https://ncbi.nlm.nih.gov/pubmed/27748448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35539
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