Discovery of ONO-7300243 from a Novel Class of Lysophosphatidic Acid Receptor 1 Antagonists: From Hit to Lead

[Image: see text] Lysophosphatidic acid (LPA) evokes various physiological responses through a series of G protein-coupled receptors known as LPA(1–6). A high throughput screen against LPA(1) gave compound 7a as a hit. The subsequent optimization of 7a led to ONO-7300243 (17a) as a novel, potent LPA...

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Publicat a:ACS Med Chem Lett
Autors principals: Terakado, Masahiko, Suzuki, Hidehiro, Hashimura, Kazuya, Tanaka, Motoyuki, Ueda, Hideyuki, Kohno, Hiroshi, Fujimoto, Taku, Saga, Hiroshi, Nakade, Shinji, Habashita, Hiromu, Takaoka, Yoshikazu, Seko, Takuya
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2016
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066152/
https://ncbi.nlm.nih.gov/pubmed/27774128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00225
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