Evaluation of the Antigen-Experienced B-Cell Receptor Repertoire in Healthy Children and Adults

Upon antigen recognition via their B cell receptor (BR), B cells migrate to the germinal center where they undergo somatic hypermutation (SHM) to increase their affinity for the antigen, and class switch recombination (CSR) to change the effector function of the secreted antibodies. These steps are...

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Publicado en:Front Immunol
Autores principales: IJspeert, Hanna, van Schouwenburg, Pauline A., van Zessen, David, Pico-Knijnenburg, Ingrid, Driessen, Gertjan J., Stubbs, Andrew P., van der Burg, Mirjam
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2016
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066086/
https://ncbi.nlm.nih.gov/pubmed/27799928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00410
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