TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection

Neutralization or deletion of tumor necrosis factor (TNF) causes loss of control of intracellular pathogens in mice and humans, but the underlying mechanisms are incompletely understood. Here, we found that TNF antagonized alternative activation of macrophages and dendritic cells by IL-4. TNF inhibi...

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Publicado no:Cell Rep
Main Authors: Schleicher, Ulrike, Paduch, Katrin, Debus, Andrea, Obermeyer, Stephanie, König, Till, Kling, Jessica C., Ribechini, Eliana, Dudziak, Diana, Mougiakakos, Dimitrios, Murray, Peter J., Ostuni, Renato, Körner, Heinrich, Bogdan, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065922/
https://ncbi.nlm.nih.gov/pubmed/27117406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.001
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