Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

Toll-like receptor (TLR) signaling in macrophages is required for antipathogen responses, including the biosynthesis of nitric oxide from arginine, and is essential for immunity to Mycobacterium tuberculosis, Toxoplasma gondii and other intracellular pathogens. Here we report a ‘loophole’ in the TLR...

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Detalhes bibliográficos
Main Authors: El Kasmi, Karim C, Qualls, Joseph E, Pesce, John T, Smith, Amber M, Thompson, Robert W, Henao-Tamayo, Marcela, Basaraba, Randall J, König, Till, Schleicher, Ulrike, Koo, Mi-Sun, Kaplan, Gilla, Fitzgerald, Katherine A, Tuomanen, Elaine I, Orme, Ian M, Kanneganti, Thirumala-Devi, Bogdan, Christian, Wynn, Thomas A, Murray, Peter J
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584974/
https://ncbi.nlm.nih.gov/pubmed/18978793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1671
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