Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: Evidence from the Long Life Family Study

The apolipoprotein E (apoE) is a classic example of a gene exhibiting pleiotropism. We examine potential pleiotropic associations of the apoE2 allele in three biodemographic cohorts of long-living individuals, offspring, and spouses from the Long Life Family Study, and intermediate mechanisms, which...

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Vydáno v:Biogerontology
Hlavní autoři: Kulminski, Alexander M., Raghavachari, Nalini, Arbeev, Konstantin G., Culminskaya, Irina, Arbeeva, Liubov, Wu, Deqing, Ukraintseva, Svetlana V., Christensen, Kaare, Yashin, Anatoliy I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065761/
https://ncbi.nlm.nih.gov/pubmed/27447179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10522-016-9659-3
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