Corticosteroids Mediate Heart Failure-Induced Depression through Reduced σ1-Receptor Expression

Cardiovascular diseases are risk factors for depression in humans. We recently proposed that σ(1) receptor (σ(1)R) stimulation rescued cardiac hypertrophy and heart failure induced by transverse aortic constriction (TAC) in mice. Importantly, σ(1)R stimulation reportedly ameliorates depression-like...

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Veröffentlicht in:PLoS One
Hauptverfasser: Shinoda, Yasuharu, Tagashira, Hideaki, Bhuiyan, Md. Shenuarin, Hasegawa, Hideyuki, Kanai, Hiroshi, Zhang, Chen, Han, Feng, Fukunaga, Kohji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065174/
https://ncbi.nlm.nih.gov/pubmed/27741227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163992
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