Stimulation of the Sigma-1 Receptor by DHEA Enhances Synaptic Efficacy and Neurogenesis in the Hippocampal Dentate Gyrus of Olfactory Bulbectomized Mice

Dehydroepiandrosterone (DHEA) is the most abundant neurosteroid synthesized de novo in the central nervous system. We previously reported that stimulation of the sigma-1 receptor by DHEA improves cognitive function by activating calcium/calmodulin-dependent protein kinase II (CaMKII), protein kinase...

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Detalhes bibliográficos
Main Authors: Moriguchi, Shigeki, Shinoda, Yasuharu, Yamamoto, Yui, Sasaki, Yuzuru, Miyajima, Kosuke, Tagashira, Hideaki, Fukunaga, Kohji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620380/
https://ncbi.nlm.nih.gov/pubmed/23593332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060863
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