Mechanistic Insights into Archaeal and Human Argonaute Substrate Binding and Cleavage Properties

Argonaute (Ago) proteins from all three domains of life are key players in processes that specifically regulate cellular nucleic acid levels. Some of these Ago proteins, among them human Argonaute2 (hAgo2) and Ago from the archaeal organism Methanocaldococcus jannaschii (MjAgo), are able to cleave n...

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Bibliographic Details
Published in:PLoS One
Main Authors: Willkomm, Sarah, Zander, Adrian, Grohmann, Dina, Restle, Tobias
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065165/
https://ncbi.nlm.nih.gov/pubmed/27741323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164695
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