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Mechanistic Insights into Archaeal and Human Argonaute Substrate Binding and Cleavage Properties

Argonaute (Ago) proteins from all three domains of life are key players in processes that specifically regulate cellular nucleic acid levels. Some of these Ago proteins, among them human Argonaute2 (hAgo2) and Ago from the archaeal organism Methanocaldococcus jannaschii (MjAgo), are able to cleave n...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Willkomm, Sarah, Zander, Adrian, Grohmann, Dina, Restle, Tobias
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065165/
https://ncbi.nlm.nih.gov/pubmed/27741323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164695
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