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Cross-Neutralising Nanobodies Bind to a Conserved Pocket in the Hemagglutinin Stem Region Identified Using Yeast Display and Deep Mutational Scanning

Cross-neutralising monoclonal antibodies against influenza hemagglutinin (HA) are of considerable interest as both therapeutics and diagnostic tools. We have recently described five different single domain antibodies (nanobodies) which share this cross-neutralising activity and suggest their small s...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gaiotto, Tiziano, Hufton, Simon E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065140/
https://ncbi.nlm.nih.gov/pubmed/27741319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164296
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