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Glycoengineering of E-selectin ligands by intracellular versus extracellular fucosylation differentially affects osteotropism of human mesenchymal stem cells

Human mesenchymal stem cells (MSCs) hold great promise in cellular therapeutics for skeletal diseases but lack expression of E-selectin ligands that direct homing of blood-borne cells to bone marrow. Previously, we described a method to engineer E-selectin ligands on the MSC surface by exofucosylati...

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Vydáno v:Stem Cells
Hlavní autoři: Dykstra, Brad, Lee, Jungmin, Mortensen, Luke J., Yu, Haixiao, Wu, Zhengliang L., Lin, Charles P., Rossi, Derrick J., Sackstein, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064874/
https://ncbi.nlm.nih.gov/pubmed/27335219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2435
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