Stage-specific demethylation in primordial germ cells safeguards against precocious differentiation

Remodeling DNA methylation in mammalian genomes can be global as seen in pre-implantation embryos and primordial germ cells (PGCs), or locus-specific, which can regulate neighboring gene expression. In PGCs global and locus-specific DNA demethylation occur in sequential stages, with an initial globa...

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發表在:Dev Cell
Main Authors: Hargan-Calvopina, Joseph, Taylor, Sara, Cook, Helene, Hu, Zhongxun, Lee, Serena A, Yen, Ming-Ren, Chiang, Yih-Shien, Chen, Pao-Yang, Clark, Amander T
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064860/
https://ncbi.nlm.nih.gov/pubmed/27618282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2016.07.019
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