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Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency

Common strategy of genome-wide association studies (GWAS) relying on large samples faces difficulties, which raise concerns that GWAS have exhausted their potential, particularly for complex traits. Here, we examine the efficiency of the traditional sample-size-centered strategy in GWAS of these tra...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kulminski, Alexander M., Loika, Yury, Culminskaya, Irina, Arbeev, Konstantin G., Ukraintseva, Svetlana V., Stallard, Eric, Yashin, Anatoliy I.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064392/
https://ncbi.nlm.nih.gov/pubmed/27739495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35390
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