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Senescence Mediated by p16(INK4a) Impedes Reprogramming of Human Corneal Endothelial Cells into Neural Crest Progenitors
Human corneal endothelial cells (HCECs) have limited proliferative capacity due to “contact-inhibition” at G1 phase. Such contact-inhibition can be delayed from Day 21 to Day 42 by switching EGF-containing SHEM to LIF/bFGF-containing MESCM through transient activation of LIF-JAK1-STAT3 signaling tha...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5064359/ https://ncbi.nlm.nih.gov/pubmed/27739458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35166 |
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