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A Facile, Improved Synthesis of Sildenafil and Its Analogues

This paper describes the facile synthesis of sildenafil citrate (1) and its related compounds through an improved chlorosulfonation reaction using chlorosulfonic acid and thionyl chloride. This synthesis results in pure sildenafil with high yield. The structures of the compounds were determined with...

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Dettagli Bibliografici
Pubblicato in:Sci Pharm
Autori principali: Raghava Reddy, Ambati. V., Srinivas, Garaga, Takshinamoorthy, Chandiran, Gupta Peruri, Badarinadh, Naidu, Andra
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064236/
https://ncbi.nlm.nih.gov/pubmed/28117311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/scipharm84030447
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