KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

Most small-molecule inhibitors of voltage-gated ion channels display poor subtype specificity because they bind to highly conserved residues located in the channel's central cavity. Using a combined approach of scanning mutagenesis, electrophysiology, chemical ligand modification, chemical cros...

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Published in:Nat Commun
Main Authors: Wrobel, Eva, Rothenberg, Ina, Krisp, Christoph, Hundt, Franziska, Fraenzel, Benjamin, Eckey, Karina, Linders, Joannes T. M., Gallacher, David J., Towart, Rob, Pott, Lutz, Pusch, Michael, Yang, Tao, Roden, Dan M., Kurata, Harley T., Schulze-Bahr, Eric, Strutz-Seebohm, Nathalie, Wolters, Dirk, Seebohm, Guiscard
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064022/
https://ncbi.nlm.nih.gov/pubmed/27731317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12795
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