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Substance P is increased in patients with sickle cell disease and associated with haemolysis and hydroxycarbamide use
Sickle cell disease (SCD) pain transitions from acute to chronic for unknown reasons. Chronic elevation of the pain neurotransmitter substance P (SP) sensitizes pain nociceptors. We evaluated SP levels in controls and SCD patients during baseline and acute pain and investigated associations between...
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| Publicado no: | Br J Haematol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5063705/ https://ncbi.nlm.nih.gov/pubmed/27539682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.14300 |
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