Prevalence of ESR1 Mutations in Cell-Free DNA and Outcomes in Metastatic Breast Cancer: A Secondary Analysis of the BOLERO-2 Clinical Trial

IMPORTANCE: Estrogen receptor α (ESR1) mutations found in metastatic breast cancer (MBC) promote ligand-independent receptor activation and resistance to estrogen-deprivation therapy in laboratory models. The prevalence of these mutations and their potential impact on clinical outcomes has not been...

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Bibliografiske detaljer
Udgivet i:JAMA Oncol
Main Authors: Chandarlapaty, Sarat, Chen, David, He, Wei, Sung, Patricia, Samoila, Aliaksandra, You, Daoqi, Bhatt, Trusha, Patel, Parul, Voi, Maurizio, Gnant, Michael, Hortobagyi, Gabriel, Baselga, José, Moynahan, Mary Ellen
Format: Artigo
Sprog:Inglês
Udgivet: American Medical Association 2016
Fag:
Original Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063698/
https://ncbi.nlm.nih.gov/pubmed/27532364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2016.1279
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